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Health Care Innovation Day: Igniting an Interoperable Health System was sponsored by the West Health Institute and the Department of Health and Human Services Office of the National Coordinator for Health Information Technology in Washington, D.C., on Feb. 6, 2014. This article presents themes from Innovation Day including the adverse impact that poor interoperability has on patient safety, clinician performance and hospital operational performance. Next the article highlights lessons learned from other industries that have dealt with interoperability challenges including telecom, national intelligence and music. Finally, the article synthesizes in a visual format a key interoperability use case that combines Veterans Affairs/ Centers for Medicare & Medicaid Services Blue Button capabilities with the smartphone app marketplace to empower consumers and clinicians. This use case can be realized and adopted by multiple health systems in the short term, fosters consumer and clinician empowerment and advances the realization of the Institutes of Medicine vision for a Learning Health System.